Teshome works for The Task Force for Global Health as Regional Director for Africa since June 2011. He has more than 40 years of global public health experience, most of which are in disease prevention, control and eradication programs. He started his career as a public health professional with the Ministry of Health Ethiopia and assumed various positions in programs like Smallpox Eradication and Immunization (EPI) and later joined The Carter Center where he led the Ethiopia office as a founding Country Representative for 17 years. Teshome authored more than 105 scientific papers including four book chapters.
He is a Fellow of the Ethiopian Academy of Sciences and American Society of Tropical Medicine & Hygiene (FASTMH). Teshome holds a faculty appointment as Honorary Associate Professor with Arbaminch University and Adjunct Associate Professor with Debre Berhan University. He is a co-chair of the Regional Program Advisory Group (RPAG) for NTDs with ESPEN/WHO-AFRO. As of 1 July 2025, he has been working as a Scientific Committee member of the Global Health EDCTP3 Joint Undertaking.